BDBM243348 4-{5-[2-(2-Morpholin-4- yl-ethoxy)-5-(4-thiophen- 2-yl-pyrimidin-2- ylamino)-phenyl]-oxazol- 2-yl}-4,7-diaza- spiro[2.5]octan-8-one::US10053455, 004

SMILES: O=C1NCCN(c2ncc(o2)-c2cc(Nc3nccc(n3)-c3cccs3)ccc2OCCN2CCOCC2)C11CC1

InChI Key: InChIKey=VKTDVSNHFOAJOG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243348   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM243348 (4-{5-[2-(2-Morpholin-4- yl-ethoxy)-5-(4-thiophen- ...) Show SMILES O=C1NCCN(c2ncc(o2)-c2cc(Nc3nccc(n3)-c3cccs3)ccc2OCCN2CCOCC2)C11CC1 Show InChI InChI=1S/C29H31N7O4S/c37-26-29(6-7-29)36(10-9-30-26)28-32-19-24(40-28)21-18-20(3-4-23(21)39-16-13-35-11-14-38-15-12-35)33-27-31-8-5-22(34-27)25-2-1-17-41-25/h1-5,8,17-19H,6-7,9-16H2,(H,30,37)(H,31,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	7.8	25
AB SCIENCE US Patent					Assay Description SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...				US Patent US10053455 (2018) BindingDB Entry DOI: 10.7270/Q27946PV
					More data for this Ligand-Target Pair