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SMILES: Oc1cc(CN(c2ccc(cc2)C#N)n2cnnc2)ccc1F

InChI Key: InChIKey=DXFARUZXEUTFAT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 24340   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aromatase


(Homo sapiens (Human))		BDBM24340
PNG
(4-{[(4-fluoro-3-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Show SMILES Oc1cc(CN(c2ccc(cc2)C#N)n2cnnc2)ccc1F
Show InChI InChI=1S/C16H12FN5O/c17-15-6-3-13(7-16(15)23)9-22(21-10-19-20-11-21)14-4-1-12(8-18)2-5-14/h1-7,10-11,23H,9H2
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Article
PubMed
n/an/a 0.600n/an/an/an/a7.537



University of Bath



Assay Description
The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...

J Med Chem 50: 3540-60 (2007)


Article DOI: 10.1021/jm061462b
BindingDB Entry DOI: 10.7270/Q2348HP4
More data for this
Ligand-Target Pair