BDBM243416 N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tetrahydro-2H- pyran-4-ylamino)- cyclopropyl)thio- phene-3-carboxamide::US10053456, 50::US10414761, Example 50::US9718814, 50::US9920047, 50

SMILES: Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1

InChI Key: InChIKey=GRILTBXBBYWFBM-ZIAGYGMSSA-N

Data: 15 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 243416   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	8.0	25
Takeda Pharmaceutical Company Limited US Patent					Assay Description A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...				US Patent US9718814 (2017) BindingDB Entry DOI: 10.7270/Q21838J9
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description MAO-B: The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test co...				US Patent US10414761 (2019) BindingDB Entry DOI: 10.7270/Q2V98BFG
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	25
Takeda Pharmaceutical Company Limited US Patent					Assay Description A test compound dissolved in DMSO was added to a reaction solution (100 mM HEPES (pH 7.5), 5% glycerol, 10% DMSO) containing MAO-B enzyme (Sigma-Aldr...				US Patent US9718814 (2017) BindingDB Entry DOI: 10.7270/Q21838J9
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	8.0	25
Takeda Pharmaceutical Company Limited US Patent					Assay Description A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...				US Patent US9714241 (2017) BindingDB Entry DOI: 10.7270/Q2QZ2CZN
					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	25
Takeda Pharmaceutical Company Limited US Patent					Assay Description The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...				US Patent US9714241 (2017) BindingDB Entry DOI: 10.7270/Q2QZ2CZN
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	25
Takeda Pharmaceutical Company Limited US Patent					Assay Description The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...				US Patent US9714241 (2017) BindingDB Entry DOI: 10.7270/Q2QZ2CZN
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	8.0	25
Takeda Pharmaceutical Company Limited US Patent					Assay Description A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...				US Patent US10053456 (2018) BindingDB Entry DOI: 10.7270/Q23J3FZ4
					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	25
Takeda Pharmaceutical Company Limited US Patent					Assay Description The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...				US Patent US10053456 (2018) BindingDB Entry DOI: 10.7270/Q23J3FZ4
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	25
Takeda Pharmaceutical Company Limited US Patent					Assay Description The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...				US Patent US10053456 (2018) BindingDB Entry DOI: 10.7270/Q23J3FZ4
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q2R213PQ
					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description A test compound dissolved in DMSO was added to a reaction solution (100 mM HEPES (pH 7.5), 5% glycerol) containing MAO-A enzyme (Sigma-Aldrich Co. LL...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q2R213PQ
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description A test compound dissolved in DMSO was added to a reaction solution (100 mM HEPES (pH 7.5), 5% glycerol, 10% DMSO) containing MAO-B enzyme (Sigma-Aldr...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q2R213PQ
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description LSD1: A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and...				US Patent US10414761 (2019) BindingDB Entry DOI: 10.7270/Q2V98BFG
					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description MAO-A: The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test co...				US Patent US10414761 (2019) BindingDB Entry DOI: 10.7270/Q2V98BFG
					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM243416 (N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- (tet...) Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCOCC2)s1 |r| Show InChI InChI=1S/C17H21N3O2S2/c1-10-18-8-16(24-10)20-17(21)11-6-15(23-9-11)13-7-14(13)19-12-2-4-22-5-3-12/h6,8-9,12-14,19H,2-5,7H2,1H3,(H,20,21)/t13-,14-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	25
Takeda Pharmaceutical Company Limited US Patent					Assay Description A test compound dissolved in DMSO was added to a reaction solution (100 mM HEPES (pH 7.5), 5% glycerol) containing MAO-A enzyme (Sigma-Aldrich Co. LL...				US Patent US9718814 (2017) BindingDB Entry DOI: 10.7270/Q21838J9
					More data for this Ligand-Target Pair