BDBM244137 US9428492, 10::US9428492, 10a::US9428492, 10b
SMILES: CC(O)c1nc(C)nn1-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
InChI Key: InChIKey=PUPQIAGHGHGYRI-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human)) | BDBM244137 (US9428492, 10 | US9428492, 10a | US9428492, 10b) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.130 | -13.5 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S... | US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human)) | BDBM244137 (US9428492, 10 | US9428492, 10a | US9428492, 10b) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.210 | -13.2 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S... | US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human)) | BDBM244137 (US9428492, 10 | US9428492, 10a | US9428492, 10b) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.390 | -12.8 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S... | US Patent US9428492 (2016) BindingDB Entry DOI: 10.7270/Q2HD7TKM | |||||||||||
More data for this Ligand-Target Pair |