BDBM24419 (3R,5R)-7-[2-(4-fluorophenyl)-4-({[3-(2-fluorophenyl)phenyl]methyl}carbamoyl)-5-(propan-2-yl)-1H-imidazol-1-yl]-3,5-dihydroxyheptanoic acid::Imidazole Series 1 Compound, 6
SMILES: CC(C)c1c(nc(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(O)=O)C(=O)NCc1cccc(c1)-c1ccccc1F
InChI Key: InChIKey=JGYFNJJVXLVBOL-CLJLJLNGSA-N
Data: 1 ITC
Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kcal/mole | -TΔS° kcal/mole | ΔH° kcal/mole | log K | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human)) | BDBM24419 ((3R,5R)-7-[2-(4-fluorophenyl)-4-({[3-(2-fluorophen...) | GoogleScholar PDB | KEGG PC cid PC sid | -10.6 | -1.69 | -8.89 | 7.66 | 7.20 | 30 | |
Pfizer Inc. | J Med Chem 51: 3804-13 (2008) |