BDBM244233 US9428501, 57
SMILES: COc1ccc(CN2CCC(CC2)n2cc3cc(ccc3n2)C(=O)N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cn1
InChI Key: InChIKey=WIHQKPXLISMAJC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM244233 (US9428501, 57) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Astellas Pharma Inc. US Patent | Assay Description Human PIK3CA mutation-positive breast cancer cell line MDA-MB-453 cells were subcutaneously implanted into nude mice, MDA-MB-453 tumor was excised, a... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM244233 (US9428501, 57) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. US Patent | Assay Description In order to make human PIK3 CA mutation-positive breast cancer cell line MDA-MB-453 cells become 500 cells per well in a 384 well non-adhesive plate ... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human)) | BDBM244233 (US9428501, 57) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | 37 |
Astellas Pharma Inc. US Patent | Assay Description In order to make MDA-MB-453 cell become 15000 cells per well, each 36 μl was seeded in Leibovitz's L-15 medium including 10% fetal bovine serum (m... | US Patent US9428501 (2016) BindingDB Entry DOI: 10.7270/Q28051JK | |||||||||||
More data for this Ligand-Target Pair |