BDBM24428 (3R,5R)-7-[3-(4-fluorophenyl)-1-methyl-4-phenyl-5-[(4-sulfamoylphenyl)carbamoyl]-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid::Pyrrole Series 5 Compound, 15
SMILES: Cn1c(CC[C@@H](O)C[C@@H](O)CC(O)=O)c(c(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccccc1)-c1ccc(F)cc1
InChI Key: InChIKey=JUORHLUKTSAMGI-DNQXCXABSA-N
Data: 1 ITC
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kcal/mole | -TΔS° kcal/mole | ΔH° kcal/mole | log K | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) (Homo sapiens (Human)) | BDBM24428 ((3R,5R)-7-[3-(4-fluorophenyl)-1-methyl-4-phenyl-5-...) | GoogleScholar PDB | KEGG PC cid PC sid | -10.5 | 3.10 | -13.7 | 7.58 | 7.20 | 30 | |
Pfizer Inc. | J Med Chem 51: 3804-13 (2008) |