BDBM244602 US10226449, cpd 211::US9428502, 211

SMILES: Cc1ccc(cc1-c1[nH]c(nc1C#N)C1CCOCC1)C(=O)N1CC(C1)c1ccc(cc1)C#N

InChI Key: InChIKey=URNMDMNSTFPKSL-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 244602   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fatty acid synthase (Homo sapiens (Human))	BDBM244602 (US10226449, cpd 211 | US9428502, 211) Show SMILES Cc1ccc(cc1-c1[nH]c(nc1C#N)C1CCOCC1)C(=O)N1CC(C1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H25N5O2/c1-17-2-5-21(27(33)32-15-22(16-32)19-6-3-18(13-28)4-7-19)12-23(17)25-24(14-29)30-26(31-25)20-8-10-34-11-9-20/h2-7,12,20,22H,8-11,15-16H2,1H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	4
3-V Biosciences, Inc. US Patent					Assay Description The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...				US Patent US9428502 (2016) BindingDB Entry DOI: 10.7270/Q20G3J23
					More data for this Ligand-Target Pair
NS3 serine protease (NS3) (Hepatitis C Virus (Virus))	BDBM244602 (US10226449, cpd 211 | US9428502, 211) Show SMILES Cc1ccc(cc1-c1[nH]c(nc1C#N)C1CCOCC1)C(=O)N1CC(C1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H25N5O2/c1-17-2-5-21(27(33)32-15-22(16-32)19-6-3-18(13-28)4-7-19)12-23(17)25-24(14-29)30-26(31-25)20-8-10-34-11-9-20/h2-7,12,20,22H,8-11,15-16H2,1H3,(H,30,31)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Conforma Therapeutics Corporation					Assay Description The antiviral activities of the compounds were assessed using the HCV1b replicon system. The replicon was constructed using the ET (luc-ubi-neo/ET) c...				J Med Chem 49: 5352-62 (2006) BindingDB Entry DOI: 10.7270/Q27M0B78
					More data for this Ligand-Target Pair
Fatty acid synthase (Homo sapiens (Human))	BDBM244602 (US10226449, cpd 211 | US9428502, 211) Show SMILES Cc1ccc(cc1-c1[nH]c(nc1C#N)C1CCOCC1)C(=O)N1CC(C1)c1ccc(cc1)C#N Show InChI InChI=1S/C27H25N5O2/c1-17-2-5-21(27(33)32-15-22(16-32)19-6-3-18(13-28)4-7-19)12-23(17)25-24(14-29)30-26(31-25)20-8-10-34-11-9-20/h2-7,12,20,22H,8-11,15-16H2,1H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Conforma Therapeutics Corporation					Assay Description FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...				J Med Chem 49: 5352-62 (2006) BindingDB Entry DOI: 10.7270/Q27M0B78
					More data for this Ligand-Target Pair