BDBM24517 (2E,5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one::Thiazole analogue, 4
SMILES: [O-][N+](=O)c1ccc(\C=C2\S\C(NC2=O)=N\c2nccs2)cc1
InChI Key: InChIKey=MINTVBBMBYDMCN-JXMROGBWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM24517 ((2E,5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thia...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.74E+5 | -4.53 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Aristotle University | Assay Description SHP-2 inhibitory activity was tested using human recombinant GST-fusion SHP-2 (Calbiochem). Test compound was preincubated with enzyme mixture before... | J Med Chem 51: 5221-8 (2008) Article DOI: 10.1021/jm8004306 BindingDB Entry DOI: 10.7270/Q2251GGD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lipoxygenase-1 (Glycine max (soybean)) | BDBM24517 ((2E,5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thia...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.51E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexander Technological Education Institute of Thessaloniki Curated by ChEMBL | Assay Description Inhibition of soybean LOX type 1 pre-incubated for 4 mins at 7x10'-7 w/v concentration assessed as inhibition of sodium linoleate to 13-hydroperoxyli... | Eur J Med Chem 47: 111-24 (2012) Article DOI: 10.1016/j.ejmech.2011.10.029 BindingDB Entry DOI: 10.7270/Q2K937ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep)) | BDBM24517 ((2E,5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thia...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.41E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexander Technological Education Institute of Thessaloniki Curated by ChEMBL | Assay Description Inhibition of ovine COX1 assessed as PGF2alpha production by enzyme immunoassay | Eur J Med Chem 47: 111-24 (2012) Article DOI: 10.1016/j.ejmech.2011.10.029 BindingDB Entry DOI: 10.7270/Q2K937ZK | |||||||||||
More data for this Ligand-Target Pair |