BDBM24698 4-aminopyrazolylpyrimidine analogue, 10d::5-bromo-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-N-[(2-methoxyphenyl)methyl]pyrimidine-2,4-diamine

SMILES: COc1ccccc1CNc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1

InChI Key: InChIKey=OOBAQMLMJUYICG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 24698   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM24698 (4-aminopyrazolylpyrimidine analogue, 10d | 5-bromo...) Show SMILES COc1ccccc1CNc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1 Show InChI InChI=1S/C18H19BrN6O/c1-26-15-5-3-2-4-12(15)9-20-18-21-10-13(19)17(23-18)22-16-8-14(24-25-16)11-6-7-11/h2-5,8,10-11H,6-7,9H2,1H3,(H3,20,21,22,23,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	7.4	22
AstraZeneca					Assay Description TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...				J Med Chem 51: 4672-84 (2008) Article DOI: 10.1021/jm800343j BindingDB Entry DOI: 10.7270/Q2RN365V
					More data for this Ligand-Target Pair