BDBM247406 US9452985, THK-5151
SMILES: CNc1ccc(cn1)-c1ccc2cc(OCC(O)CF)ccc2n1
InChI Key: InChIKey=DLVXFZWSPCOWSN-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tau (Homo sapiens (Human)) | BDBM247406 (US9452985, THK-5151) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 40.1 | -10.1 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
GE Healthcare Limited US Patent | Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a... | US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM | |||||||||||
More data for this Ligand-Target Pair |