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BDBM247406 US9452985, THK-5151

SMILES: CNc1ccc(cn1)-c1ccc2cc(OCC(O)CF)ccc2n1

InChI Key: InChIKey=DLVXFZWSPCOWSN-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 247406   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tau


(Homo sapiens (Human))
BDBM247406
PNG
(US9452985, THK-5151)
Show SMILES CNc1ccc(cn1)-c1ccc2cc(OCC(O)CF)ccc2n1
Show InChI InChI=1S/C18H18FN3O2/c1-20-18-7-3-13(10-21-18)17-5-2-12-8-15(4-6-16(12)22-17)24-11-14(23)9-19/h2-8,10,14,23H,9,11H2,1H3,(H,20,21)
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
40.1 -10.1n/an/an/an/an/an/a25



GE Healthcare Limited

US Patent


Assay Description
For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...


US Patent US9452985 (2016)


BindingDB Entry DOI: 10.7270/Q2FB51VM
More data for this
Ligand-Target Pair