BDBM247406 US9452985, THK-5151

SMILES: CNc1ccc(cn1)-c1ccc2cc(OCC(O)CF)ccc2n1

InChI Key: InChIKey=DLVXFZWSPCOWSN-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 247406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tau (Homo sapiens (Human))	BDBM247406 (US9452985, THK-5151) Show SMILES CNc1ccc(cn1)-c1ccc2cc(OCC(O)CF)ccc2n1 Show InChI InChI=1S/C18H18FN3O2/c1-20-18-7-3-13(10-21-18)17-5-2-12-8-15(4-6-16(12)22-17)24-11-14(23)9-19/h2-8,10,14,23H,9,11H2,1H3,(H,20,21)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	40.1	-10.1	n/a	n/a	n/a	n/a	n/a	n/a	25
GE Healthcare Limited US Patent					Assay Description For tau imaging probes other than THK-5105, binding to K18-ΔK280 aggregates was evaluated with a competitive binding test using [18F] THK-5105 a...				US Patent US9452985 (2016) BindingDB Entry DOI: 10.7270/Q2FB51VM
					More data for this Ligand-Target Pair