BDBM2487 2-(cyclopentylamino)-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydropyrimidin-4-one::2-Cyclopentylamino-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydropyrimidin-4(3H)-one::F2-NH-DABO 9c

SMILES: CC(c1cc(=O)[nH]c(NC2CCCC2)n1)c1c(F)cccc1F

InChI Key: InChIKey=ITIVZMJXVUFETB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2487   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM2487 (2-(cyclopentylamino)-6-[1-(2,6-difluorophenyl)ethy...) Show SMILES CC(c1cc(=O)[nH]c(NC2CCCC2)n1)c1c(F)cccc1F Show InChI InChI=1S/C17H19F2N3O/c1-10(16-12(18)7-4-8-13(16)19)14-9-15(23)22-17(21-14)20-11-5-2-3-6-11/h4,7-11H,2-3,5-6H2,1H3,(H2,20,21,22,23)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description Inhibitory concentration required to inhibit the HIV-1 reverse transcriptase activity				J Med Chem 47: 928-34 (2004) Article DOI: 10.1021/jm0309856 BindingDB Entry DOI: 10.7270/Q26W988R
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM2487 (2-(cyclopentylamino)-6-[1-(2,6-difluorophenyl)ethy...) Show SMILES CC(c1cc(=O)[nH]c(NC2CCCC2)n1)c1c(F)cccc1F Show InChI InChI=1S/C17H19F2N3O/c1-10(16-12(18)7-4-8-13(16)19)14-9-15(23)22-17(21-14)20-11-5-2-3-6-11/h4,7-11H,2-3,5-6H2,1H3,(H2,20,21,22,23)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	7.8	37
Universita degli Studi di Roma La Sapienza					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 47: 928-34 (2004) Article DOI: 10.1021/jm0309856 BindingDB Entry DOI: 10.7270/Q26W988R
					More data for this Ligand-Target Pair