BDBM24877 2-(5-{1-[(4-{2-methoxy-6-phenylpyrido[2,3-d]pyrimidin-7-yl}phenyl)methyl]piperidin-4-yl}-4H-1,2,4-triazol-3-yl)pyridine::Pyridopyrimidine, 14a
SMILES: COc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
InChI Key: InChIKey=VOHKPPOYXDJURU-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human)) | BDBM24877 (2-(5-{1-[(4-{2-methoxy-6-phenylpyrido[2,3-d]pyrimi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d... | Bioorg Med Chem Lett 18: 1274-9 (2008) Article DOI: 10.1016/j.bmcl.2008.01.054 BindingDB Entry DOI: 10.7270/Q2G73C02 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM24877 (2-(5-{1-[(4-{2-methoxy-6-phenylpyrido[2,3-d]pyrimi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 23.6 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Merck Research Laboratories | Assay Description Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d... | Bioorg Med Chem Lett 18: 1274-9 (2008) Article DOI: 10.1016/j.bmcl.2008.01.054 BindingDB Entry DOI: 10.7270/Q2G73C02 | |||||||||||
More data for this Ligand-Target Pair |