BDBM24889 2,3,5-trisubstituted pyridine, 10e::5-{5-phenyl-6-[4-({4-[4-(pyrazin-2-yl)-1H-pyrazol-1-yl]piperidin-1-yl}methyl)phenyl]pyridin-3-yl}-1,3,4-thiadiazol-2-amine

SMILES: Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3cc(cn3)-c3cnccn3)cc2)c(c1)-c1ccccc1

InChI Key: InChIKey=JEBHQRKVJAFLBR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 24889   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM24889 (2,3,5-trisubstituted pyridine, 10e | 5-{5-phenyl-6...) Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3cc(cn3)-c3cnccn3)cc2)c(c1)-c1ccccc1 Show InChI InChI=1S/C32H29N9S/c33-32-39-38-31(42-32)25-16-28(23-4-2-1-3-5-23)30(36-17-25)24-8-6-22(7-9-24)20-40-14-10-27(11-15-40)41-21-26(18-37-41)29-19-34-12-13-35-29/h1-9,12-13,16-19,21,27H,10-11,14-15,20H2,(H2,33,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...				Bioorg Med Chem Lett 18: 2194-7 (2008) Article DOI: 10.1016/j.bmcl.2007.12.040 BindingDB Entry DOI: 10.7270/Q2BG2M8B
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM24889 (2,3,5-trisubstituted pyridine, 10e | 5-{5-phenyl-6...) Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3cc(cn3)-c3cnccn3)cc2)c(c1)-c1ccccc1 Show InChI InChI=1S/C32H29N9S/c33-32-39-38-31(42-32)25-16-28(23-4-2-1-3-5-23)30(36-17-25)24-8-6-22(7-9-24)20-40-14-10-27(11-15-40)41-21-26(18-37-41)29-19-34-12-13-35-29/h1-9,12-13,16-19,21,27H,10-11,14-15,20H2,(H2,33,39)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	172	n/a	n/a	n/a	n/a	7.5	22
Merck Research Laboratories					Assay Description Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...				Bioorg Med Chem Lett 18: 2194-7 (2008) Article DOI: 10.1016/j.bmcl.2007.12.040 BindingDB Entry DOI: 10.7270/Q2BG2M8B
					More data for this Ligand-Target Pair