null

SMILES: Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(ccc3-n3cccn3)C(F)(F)F)cn2)cc1

InChI Key: InChIKey=LMRIJLJOVVEKIC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249319   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249319 (US10300060, Example 9-1 | US10765676, Example 9-1 ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(ccc3-n3cccn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C27H19ClF3N7O2/c28-18-13-21(25(32)34-14-18)16-2-6-20(7-3-16)40-24-9-5-19(15-33-24)36-26(39)37-22-12-17(27(29,30)31)4-8-23(22)38-11-1-10-35-38/h1-15H,(H2,32,34)(H2,36,37,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	37
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9463192 (2016) BindingDB Entry DOI: 10.7270/Q22Z14FR
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249319 (US10300060, Example 9-1 | US10765676, Example 9-1 ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(ccc3-n3cccn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C27H19ClF3N7O2/c28-18-13-21(25(32)34-14-18)16-2-6-20(7-3-16)40-24-9-5-19(15-33-24)36-26(39)37-22-12-17(27(29,30)31)4-8-23(22)38-11-1-10-35-38/h1-15H,(H2,32,34)(H2,36,37,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9763943 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1P0X
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249319 (US10300060, Example 9-1 | US10765676, Example 9-1 ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(ccc3-n3cccn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C27H19ClF3N7O2/c28-18-13-21(25(32)34-14-18)16-2-6-20(7-3-16)40-24-9-5-19(15-33-24)36-26(39)37-22-12-17(27(29,30)31)4-8-23(22)38-11-1-10-35-38/h1-15H,(H2,32,34)(H2,36,37,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US10765676 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249319 (US10300060, Example 9-1 | US10765676, Example 9-1 ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(ccc3-n3cccn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C27H19ClF3N7O2/c28-18-13-21(25(32)34-14-18)16-2-6-20(7-3-16)40-24-9-5-19(15-33-24)36-26(39)37-22-12-17(27(29,30)31)4-8-23(22)38-11-1-10-35-38/h1-15H,(H2,32,34)(H2,36,37,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd					Assay Description On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...				Bioorg Med Chem Lett 19: 1654-7 (2009) BindingDB Entry DOI: 10.7270/Q2JH3PGF
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249319 (US10300060, Example 9-1 | US10765676, Example 9-1 ...) Show SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ccc(NC(=O)Nc3cc(ccc3-n3cccn3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C27H19ClF3N7O2/c28-18-13-21(25(32)34-14-18)16-2-6-20(7-3-16)40-24-9-5-19(15-33-24)36-26(39)37-22-12-17(27(29,30)31)4-8-23(22)38-11-1-10-35-38/h1-15H,(H2,32,34)(H2,36,37,39)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair