BDBM249328 US10300060, Example 15-52::US10765676, Example 15-52::US9463192, 15-52::US9763943, 15-52::US9993479, 15-52

SMILES: Nc1ncc(cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1)C(F)(F)F

InChI Key: InChIKey=BYSOEFKFIIAJFN-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249328   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249328 (US10300060, Example 15-52 | US10765676, Example 15...) Show SMILES Nc1ncc(cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1)C(F)(F)F Show InChI InChI=1S/C28H17F9N8O2/c29-26(30,31)15-3-6-21(45-8-7-22(44-45)28(35,36)37)20(10-15)43-24(46)42-17-12-40-25(41-13-17)47-18-4-1-14(2-5-18)19-9-16(27(32,33)34)11-39-23(19)38/h1-13H,(H2,38,39)(H2,42,43,46)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	37
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9463192 (2016) BindingDB Entry DOI: 10.7270/Q22Z14FR
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249328 (US10300060, Example 15-52 | US10765676, Example 15...) Show SMILES Nc1ncc(cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1)C(F)(F)F Show InChI InChI=1S/C28H17F9N8O2/c29-26(30,31)15-3-6-21(45-8-7-22(44-45)28(35,36)37)20(10-15)43-24(46)42-17-12-40-25(41-13-17)47-18-4-1-14(2-5-18)19-9-16(27(32,33)34)11-39-23(19)38/h1-13H,(H2,38,39)(H2,42,43,46)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9763943 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1P0X
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249328 (US10300060, Example 15-52 | US10765676, Example 15...) Show SMILES Nc1ncc(cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1)C(F)(F)F Show InChI InChI=1S/C28H17F9N8O2/c29-26(30,31)15-3-6-21(45-8-7-22(44-45)28(35,36)37)20(10-15)43-24(46)42-17-12-40-25(41-13-17)47-18-4-1-14(2-5-18)19-9-16(27(32,33)34)11-39-23(19)38/h1-13H,(H2,38,39)(H2,42,43,46)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US10765676 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249328 (US10300060, Example 15-52 | US10765676, Example 15...) Show SMILES Nc1ncc(cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1)C(F)(F)F Show InChI InChI=1S/C28H17F9N8O2/c29-26(30,31)15-3-6-21(45-8-7-22(44-45)28(35,36)37)20(10-15)43-24(46)42-17-12-40-25(41-13-17)47-18-4-1-14(2-5-18)19-9-16(27(32,33)34)11-39-23(19)38/h1-13H,(H2,38,39)(H2,42,43,46)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd					Assay Description On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...				Bioorg Med Chem Lett 19: 1654-7 (2009) BindingDB Entry DOI: 10.7270/Q2JH3PGF
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249328 (US10300060, Example 15-52 | US10765676, Example 15...) Show SMILES Nc1ncc(cc1-c1ccc(Oc2ncc(NC(=O)Nc3cc(ccc3-n3ccc(n3)C(F)(F)F)C(F)(F)F)cn2)cc1)C(F)(F)F Show InChI InChI=1S/C28H17F9N8O2/c29-26(30,31)15-3-6-21(45-8-7-22(44-45)28(35,36)37)20(10-15)43-24(46)42-17-12-40-25(41-13-17)47-18-4-1-14(2-5-18)19-9-16(27(32,33)34)11-39-23(19)38/h1-13H,(H2,38,39)(H2,42,43,46)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair