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SMILES: FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnn4cccnc34)nc2)c1)-c1cccnc1

InChI Key: InChIKey=LKVPVSYJCGEWCU-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249342   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249342 (US10300060, Example 21-13 | US10765676, Example 21...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnn4cccnc34)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C29H19F3N8O2/c30-29(31,32)20-6-9-23(19-3-1-10-33-14-19)25(13-20)39-27(41)38-21-15-35-28(36-16-21)42-22-7-4-18(5-8-22)24-17-37-40-12-2-11-34-26(24)40/h1-17H,(H2,38,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	37
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9463192 (2016) BindingDB Entry DOI: 10.7270/Q22Z14FR
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249342 (US10300060, Example 21-13 | US10765676, Example 21...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnn4cccnc34)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C29H19F3N8O2/c30-29(31,32)20-6-9-23(19-3-1-10-33-14-19)25(13-20)39-27(41)38-21-15-35-28(36-16-21)42-22-7-4-18(5-8-22)24-17-37-40-12-2-11-34-26(24)40/h1-17H,(H2,38,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9763943 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1P0X
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249342 (US10300060, Example 21-13 | US10765676, Example 21...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnn4cccnc34)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C29H19F3N8O2/c30-29(31,32)20-6-9-23(19-3-1-10-33-14-19)25(13-20)39-27(41)38-21-15-35-28(36-16-21)42-22-7-4-18(5-8-22)24-17-37-40-12-2-11-34-26(24)40/h1-17H,(H2,38,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US10765676 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249342 (US10300060, Example 21-13 | US10765676, Example 21...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnn4cccnc34)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C29H19F3N8O2/c30-29(31,32)20-6-9-23(19-3-1-10-33-14-19)25(13-20)39-27(41)38-21-15-35-28(36-16-21)42-22-7-4-18(5-8-22)24-17-37-40-12-2-11-34-26(24)40/h1-17H,(H2,38,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd					Assay Description On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...				Bioorg Med Chem Lett 19: 1654-7 (2009) BindingDB Entry DOI: 10.7270/Q2JH3PGF
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249342 (US10300060, Example 21-13 | US10765676, Example 21...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnn4cccnc34)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C29H19F3N8O2/c30-29(31,32)20-6-9-23(19-3-1-10-33-14-19)25(13-20)39-27(41)38-21-15-35-28(36-16-21)42-22-7-4-18(5-8-22)24-17-37-40-12-2-11-34-26(24)40/h1-17H,(H2,38,39,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair