BDBM249343 US10300060, Example 21-37::US10765676, Example 21-37::US9463192, 21-37::US9763943, 21-37::US9993479, 21-37

SMILES: CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)c2n1

InChI Key: InChIKey=SWDIRMSGSBDKCB-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249343   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249343 (US10300060, Example 21-37 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C31H24F3N9O2/c1-42(2)27-11-13-43-28(41-27)25(18-38-43)19-5-8-23(9-6-19)45-30-36-16-22(17-37-30)39-29(44)40-26-14-21(31(32,33)34)7-10-24(26)20-4-3-12-35-15-20/h3-18H,1-2H3,(H2,39,40,44)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	37
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9463192 (2016) BindingDB Entry DOI: 10.7270/Q22Z14FR
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249343 (US10300060, Example 21-37 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C31H24F3N9O2/c1-42(2)27-11-13-43-28(41-27)25(18-38-43)19-5-8-23(9-6-19)45-30-36-16-22(17-37-30)39-29(44)40-26-14-21(31(32,33)34)7-10-24(26)20-4-3-12-35-15-20/h3-18H,1-2H3,(H2,39,40,44)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9763943 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1P0X
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249343 (US10300060, Example 21-37 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C31H24F3N9O2/c1-42(2)27-11-13-43-28(41-27)25(18-38-43)19-5-8-23(9-6-19)45-30-36-16-22(17-37-30)39-29(44)40-26-14-21(31(32,33)34)7-10-24(26)20-4-3-12-35-15-20/h3-18H,1-2H3,(H2,39,40,44)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US10765676 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249343 (US10300060, Example 21-37 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C31H24F3N9O2/c1-42(2)27-11-13-43-28(41-27)25(18-38-43)19-5-8-23(9-6-19)45-30-36-16-22(17-37-30)39-29(44)40-26-14-21(31(32,33)34)7-10-24(26)20-4-3-12-35-15-20/h3-18H,1-2H3,(H2,39,40,44)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd					Assay Description On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...				Bioorg Med Chem Lett 19: 1654-7 (2009) BindingDB Entry DOI: 10.7270/Q2JH3PGF
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249343 (US10300060, Example 21-37 | US10765676, Example 21...) Show SMILES CN(C)c1ccn2ncc(-c3ccc(Oc4ncc(NC(=O)Nc5cc(ccc5-c5cccnc5)C(F)(F)F)cn4)cc3)c2n1 Show InChI InChI=1S/C31H24F3N9O2/c1-42(2)27-11-13-43-28(41-27)25(18-38-43)19-5-8-23(9-6-19)45-30-36-16-22(17-37-30)39-29(44)40-26-14-21(31(32,33)34)7-10-24(26)20-4-3-12-35-15-20/h3-18H,1-2H3,(H2,39,40,44)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair