BDBM249352 US10300060, Example 23-7::US10765676, Example 23-7::US9463192, 23-7::US9763943, 23-7::US9993479, 23-7

SMILES: FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4[nH]ccc4c3)nc2)c1)-c1cccnc1

InChI Key: InChIKey=DVMMNZKIWHSVNM-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249352 (US10300060, Example 23-7 | US10765676, Example 23-...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4[nH]ccc4c3)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C30H20F3N7O2/c31-30(32,33)22-5-8-25(20-2-1-10-34-14-20)26(13-22)40-28(41)39-23-16-37-29(38-17-23)42-24-6-3-18(4-7-24)21-12-19-9-11-35-27(19)36-15-21/h1-17H,(H,35,36)(H2,39,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9463192 (2016) BindingDB Entry DOI: 10.7270/Q22Z14FR
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249352 (US10300060, Example 23-7 | US10765676, Example 23-...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4[nH]ccc4c3)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C30H20F3N7O2/c31-30(32,33)22-5-8-25(20-2-1-10-34-14-20)26(13-22)40-28(41)39-23-16-37-29(38-17-23)42-24-6-3-18(4-7-24)21-12-19-9-11-35-27(19)36-15-21/h1-17H,(H,35,36)(H2,39,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US9763943 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1P0X
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249352 (US10300060, Example 23-7 | US10765676, Example 23-...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4[nH]ccc4c3)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C30H20F3N7O2/c31-30(32,33)22-5-8-25(20-2-1-10-34-14-20)26(13-22)40-28(41)39-23-16-37-29(38-17-23)42-24-6-3-18(4-7-24)21-12-19-9-11-35-27(19)36-15-21/h1-17H,(H,35,36)(H2,39,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
ONO PHARMACEUTICAL CO., LTD. US Patent					Assay Description On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...				US Patent US10765676 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249352 (US10300060, Example 23-7 | US10765676, Example 23-...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4[nH]ccc4c3)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C30H20F3N7O2/c31-30(32,33)22-5-8-25(20-2-1-10-34-14-20)26(13-22)40-28(41)39-23-16-37-29(38-17-23)42-24-6-3-18(4-7-24)21-12-19-9-11-35-27(19)36-15-21/h1-17H,(H,35,36)(H2,39,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd					Assay Description On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...				Bioorg Med Chem Lett 19: 1654-7 (2009) BindingDB Entry DOI: 10.7270/Q2JH3PGF
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM249352 (US10300060, Example 23-7 | US10765676, Example 23-...) Show SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4[nH]ccc4c3)nc2)c1)-c1cccnc1 Show InChI InChI=1S/C30H20F3N7O2/c31-30(32,33)22-5-8-25(20-2-1-10-34-14-20)26(13-22)40-28(41)39-23-16-37-29(38-17-23)42-24-6-3-18(4-7-24)21-12-19-9-11-35-27(19)36-15-21/h1-17H,(H,35,36)(H2,39,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd.					Assay Description TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...				Bioorg Med Chem 17: 2017-29 (2009) BindingDB Entry DOI: 10.7270/Q2WD42WT
					More data for this Ligand-Target Pair