BDBM249384 US9464081, 17

SMILES: [#7]-[#6](=O)-c1nn(-[#6]-[#6](=O)-[#7]-2-[#6@@H]-3-[#6]-[#6@@H]-3-[#6]-[#6@H]-2-[#6](=O)-[#7]-[#6]\[#6](F)=[#6]-2\[#6]-[#6]-[#6]-[#6]-2)c2ccccc12

InChI Key: InChIKey=HNMJNQOQXAYCNO-ZMYBRWDISA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 249384   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM249384 (US9464081, 17) Show SMILES [#7]-[#6](=O)-c1nn(-[#6]-[#6](=O)-[#7]-2-[#6@@H]-3-[#6]-[#6@@H]-3-[#6]-[#6@H]-2-[#6](=O)-[#7]-[#6]\[#6](F)=[#6]-2\[#6]-[#6]-[#6]-[#6]-2)c2ccccc12 |r| Show InChI InChI=1S/C23H26FN5O3/c24-16(13-5-1-2-6-13)11-26-23(32)19-10-14-9-18(14)29(19)20(30)12-28-17-8-4-3-7-15(17)21(27-28)22(25)31/h3-4,7-8,14,18-19H,1-2,5-6,9-12H2,(H2,25,31)(H,26,32)/t14-,18-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	128	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...				US Patent US9464081 (2016) BindingDB Entry DOI: 10.7270/Q2PN94K2
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