null
SMILES: Fc1ccc(C2CCN(CC2)C(=O)c2nnc3ccc(cn23)C#N)c(c1)C(F)(F)F
InChI Key: InChIKey=XEPOCPGPNGGIJI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249562 (US10072016, Compound 160 | US10407433, Compound 16...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.06 | n/a | n/a | n/a | n/a | 7.4 | 4 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US9434727 (2016) BindingDB Entry DOI: 10.7270/Q2F76BGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249562 (US10072016, Compound 160 | US10407433, Compound 16...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19.8 | n/a | n/a | n/a | n/a | 7.5 | 4 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte... | US Patent US9434727 (2016) BindingDB Entry DOI: 10.7270/Q2F76BGR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249562 (US10072016, Compound 160 | US10407433, Compound 16...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.06 | n/a | n/a | n/a | n/a | 7.5 | n/a |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)... | US Patent US10072016 (2018) BindingDB Entry DOI: 10.7270/Q2QJ7KBT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249562 (US10072016, Compound 160 | US10407433, Compound 16...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.06 | n/a | n/a | n/a | n/a | n/a | n/a |
The Trustees of Columbia University in the City of New York US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US10913746 (2021) BindingDB Entry DOI: 10.7270/Q2HX1GS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249562 (US10072016, Compound 160 | US10407433, Compound 16...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.06 | n/a | n/a | n/a | n/a | n/a | n/a |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US9777010 (2017) BindingDB Entry DOI: 10.7270/Q22J6F0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249562 (US10072016, Compound 160 | US10407433, Compound 16...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.06 | n/a | n/a | n/a | n/a | n/a | n/a |
The Trustees of Columbia University In The City of New York US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US10407433 (2019) BindingDB Entry DOI: 10.7270/Q2W95CKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinol-binding protein 4 (Homo sapiens (Human)) | BDBM249562 (US10072016, Compound 160 | US10407433, Compound 16...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Albany College of Pharmacy and Health Sciences Curated by ChEMBL | Assay Description Competitive displacement of 3[H]retinol from biotinylated RBP4 (unknown origin) by surface plasmon resonance analysis | J Med Chem 62: 5470-5500 (2019) Article DOI: 10.1021/acs.jmedchem.9b00352 BindingDB Entry DOI: 10.7270/Q290272Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transthyretin (Homo sapiens (Human)) | BDBM249562 (US10072016, Compound 160 | US10407433, Compound 16...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19.8 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US Patent | Assay Description Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u... | US Patent US10072016 (2018) BindingDB Entry DOI: 10.7270/Q2QJ7KBT | |||||||||||
More data for this Ligand-Target Pair |