BDBM250460 US9464044, 62

SMILES: CN(C1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1cccc(Cl)c1

InChI Key: InChIKey=FBNPZTOZHIFXBD-VMJYUYMSSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 250460   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM250460 (US9464044, 62) Show SMILES CN(C1(CC1)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)c1cccc(Cl)c1 |r,wU:8.8,TLB:18:15:8:12.11.10,7:8:12:15.16.14,17:15:12:8.9.10,THB:16:15:8:12.11.10,16:11:8:15.17.14,17:9:12:15.16.14,(-1.95,-1.73,;-1.95,-.19,;-.62,.58,;.15,1.91,;-1.39,1.91,;.72,-.19,;.72,-1.73,;2.05,.58,;3.38,-.19,;4.72,.58,;3.96,-.59,;3.94,-2.99,;2.55,-3.63,;3.38,-1.73,;4.72,-2.5,;6.04,-1.73,;5.15,-3.66,;6.04,-.19,;7.53,-2.13,;8.62,-1.04,;7.93,-3.62,;-3.29,.58,;-2.52,1.91,;-4.06,-.76,;-4.62,1.35,;-4.62,2.89,;-5.95,3.66,;-7.29,2.89,;-7.29,1.35,;-8.62,.58,;-5.95,.58,)| Show InChI InChI=1S/C22H28ClN3O4S/c1-26(31(29,30)17-4-2-3-16(23)9-17)22(5-6-22)20(28)25-18-14-7-13-8-15(18)12-21(10-13,11-14)19(24)27/h2-4,9,13-15,18H,5-8,10-12H2,1H3,(H2,24,27)(H,25,28)/t13?,14?,15?,18-,21?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	6.0	25
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION US Patent					Assay Description The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...				US Patent US9464044 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JH0
					More data for this Ligand-Target Pair