null

SMILES: NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccs4)c1)C(C3)C2

InChI Key: InChIKey=ZOOODKPNCNUQMM-LSWQQERJSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 250474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM250474 (US9464044, 102) Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4cccs4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:29:3.4.30,8:3:29:9.7.6,1:3:9:29.5.6,THB:8:7:29:3.4.30,4:3:9:29.5.6,4:5:9:3.8.30,(9.14,-.66,;8.05,-1.75,;8.45,-3.23,;6.56,-1.35,;5.67,-3.27,;4.46,-2.6,;4.48,-.2,;5.23,.96,;6.56,.19,;3.9,.19,;2.57,.96,;1.23,.19,;1.23,-1.35,;-.1,.96,;-.1,2.5,;-1.43,3.27,;-2.77,2.5,;-2.77,.96,;-4.1,.19,;-5.44,.96,;-5.44,2.5,;-4.35,2.05,;-6.77,.19,;-6.77,-1.35,;-8.23,-1.82,;-9.14,-.58,;-8.23,.67,;-1.43,.19,;3.9,-1.35,;3.07,-3.25,;5.23,-2.12,)| Show InChI InChI=1S/C22H25N3O4S2/c23-21(27)22-10-13-7-15(11-22)19(16(8-13)12-22)24-20(26)14-3-1-4-17(9-14)25-31(28,29)18-5-2-6-30-18/h1-6,9,13,15-16,19,25H,7-8,10-12H2,(H2,23,27)(H,24,26)/t13?,15?,16?,19-,22?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	6.0	25
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION US Patent					Assay Description The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...				US Patent US9464044 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JH0
					More data for this Ligand-Target Pair