null
SMILES: CC1CCCC(C1)Nc1nc(Nc2cnn(C)c2)nc2[nH]cnc12
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM250518 (US9469644, 4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.06E+4 | n/a | n/a | n/a | n/a | 7.15 | 14 |
Hoffmann-La Roche Inc. US Patent | Assay Description This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (FOrster/Flouresence Res... | US Patent US9469644 (2016) BindingDB Entry DOI: 10.7270/Q24Q7SXC | |||||||||||
More data for this Ligand-Target Pair |