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BDBM251322 US9452990, 2

SMILES: COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)\C=C\c1ccc(cc1)C#N

InChI Key: InChIKey=XVNYPQWAXTYNCM-BQYQJAHWSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 251322   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CVF-Bb Complex


(Naja kaouthia (Monocled cobra) (Naja siamensis)-Ho...)
BDBM251322
PNG
(US9452990, 2)
Show SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)\C=C\c1ccc(cc1)C#N
Show InChI InChI=1S/C24H23FN6O3/c1-33-18-13-17-21(20(25)22(18)34-2)28-24(29-23(17)27)31-11-9-30(10-12-31)19(32)8-7-15-3-5-16(14-26)6-4-15/h3-8,13H,9-12H2,1-2H3,(H2,27,28,29)/b8-7+
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...


Citation and Details
More data for this
Ligand-Target Pair