null

SMILES: Cn1ncc2c(ncnc12)-c1cnc(N)c(n1)C(=O)Nc1ncccc1N1CCC(N)CC1

InChI Key: InChIKey=DFRRTVUTEGCPAR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 251498   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C theta type (Homo sapiens (Human))	BDBM251498 (US9452998, 47) Show SMILES Cn1ncc2c(ncnc12)-c1cnc(N)c(n1)C(=O)Nc1ncccc1N1CCC(N)CC1 Show InChI InChI=1S/C21H23N11O/c1-31-20-13(9-28-31)16(26-11-27-20)14-10-25-18(23)17(29-14)21(33)30-19-15(3-2-6-24-19)32-7-4-12(22)5-8-32/h2-3,6,9-12H,4-5,7-8,22H2,1H3,(H2,23,25)(H,24,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	n/a
NOVARTIS AG US Patent					Assay Description The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...				US Patent US9452998 (2016) BindingDB Entry DOI: 10.7270/Q2C82870
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM251498 (US9452998, 47) Show SMILES Cn1ncc2c(ncnc12)-c1cnc(N)c(n1)C(=O)Nc1ncccc1N1CCC(N)CC1 Show InChI InChI=1S/C21H23N11O/c1-31-20-13(9-28-31)16(26-11-27-20)14-10-25-18(23)17(29-14)21(33)30-19-15(3-2-6-24-19)32-7-4-12(22)5-8-32/h2-3,6,9-12H,4-5,7-8,22H2,1H3,(H2,23,25)(H,24,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	7.4	n/a
NOVARTIS AG US Patent					Assay Description The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...				US Patent US9452998 (2016) BindingDB Entry DOI: 10.7270/Q2C82870
					More data for this Ligand-Target Pair