null

SMILES: CN(Cc1ccccc1)S(=O)(=O)c1csc(c1)C(=O)C(F)(F)F

InChI Key: InChIKey=UMWZEUPYBZJRSL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25178   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 6 (Homo sapiens (Human))	BDBM25178 (N-benzyl-N-methyl-5-(2,2,2-trifluoroacetyl)thiophe...) Show SMILES CN(Cc1ccccc1)S(=O)(=O)c1csc(c1)C(=O)C(F)(F)F Show InChI InChI=1S/C14H12F3NO3S2/c1-18(8-10-5-3-2-4-6-10)23(20,21)11-7-12(22-9-11)13(19)14(15,16)17/h2-7,9H,8H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	25
IRBM/Merck					Assay Description The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...				Bioorg Med Chem Lett 18: 3456-61 (2008) Article DOI: 10.1016/j.bmcl.2008.02.026 BindingDB Entry DOI: 10.7270/Q2MS3R28
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM25178 (N-benzyl-N-methyl-5-(2,2,2-trifluoroacetyl)thiophe...) Show SMILES CN(Cc1ccccc1)S(=O)(=O)c1csc(c1)C(=O)C(F)(F)F Show InChI InChI=1S/C14H12F3NO3S2/c1-18(8-10-5-3-2-4-6-10)23(20,21)11-7-12(22-9-11)13(19)14(15,16)17/h2-7,9H,8H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	8.0	37
IRBM/Merck					Assay Description The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...				Bioorg Med Chem Lett 18: 3456-61 (2008) Article DOI: 10.1016/j.bmcl.2008.02.026 BindingDB Entry DOI: 10.7270/Q2MS3R28
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Homo sapiens (Human))	BDBM25178 (N-benzyl-N-methyl-5-(2,2,2-trifluoroacetyl)thiophe...) Show SMILES CN(Cc1ccccc1)S(=O)(=O)c1csc(c1)C(=O)C(F)(F)F Show InChI InChI=1S/C14H12F3NO3S2/c1-18(8-10-5-3-2-4-6-10)23(20,21)11-7-12(22-9-11)13(19)14(15,16)17/h2-7,9H,8H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	25
IRBM/Merck					Assay Description The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...				Bioorg Med Chem Lett 18: 3456-61 (2008) Article DOI: 10.1016/j.bmcl.2008.02.026 BindingDB Entry DOI: 10.7270/Q2MS3R28
					More data for this Ligand-Target Pair
Histone deacetylase 4 [653-1084,H976Y] (Homo sapiens (Human))	BDBM25178 (N-benzyl-N-methyl-5-(2,2,2-trifluoroacetyl)thiophe...) Show SMILES CN(Cc1ccccc1)S(=O)(=O)c1csc(c1)C(=O)C(F)(F)F Show InChI InChI=1S/C14H12F3NO3S2/c1-18(8-10-5-3-2-4-6-10)23(20,21)11-7-12(22-9-11)13(19)14(15,16)17/h2-7,9H,8H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	25
IRBM/Merck					Assay Description The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...				Bioorg Med Chem Lett 18: 3456-61 (2008) Article DOI: 10.1016/j.bmcl.2008.02.026 BindingDB Entry DOI: 10.7270/Q2MS3R28
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM25178 (N-benzyl-N-methyl-5-(2,2,2-trifluoroacetyl)thiophe...) Show SMILES CN(Cc1ccccc1)S(=O)(=O)c1csc(c1)C(=O)C(F)(F)F Show InChI InChI=1S/C14H12F3NO3S2/c1-18(8-10-5-3-2-4-6-10)23(20,21)11-7-12(22-9-11)13(19)14(15,16)17/h2-7,9H,8H2,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	25
IRBM/Merck					Assay Description The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...				Bioorg Med Chem Lett 18: 3456-61 (2008) Article DOI: 10.1016/j.bmcl.2008.02.026 BindingDB Entry DOI: 10.7270/Q2MS3R28
					More data for this Ligand-Target Pair