BDBM251869 US9475806, 5-B b) (-)

SMILES: COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 251869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor B (Homo sapiens (Human))	BDBM251869 (US9475806, 5-B b) (-)) Show SMILES COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(cnc2[nH]1)C#N)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	140	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Recombinant human factor B (expressed in drosophila cells and purified using standard methods) labeled with biotin (10 nM), europium-labeled streptav...				US Patent US9475806 (2016) BindingDB Entry DOI: 10.7270/Q2KS6QG2
					More data for this Ligand-Target Pair