BDBM252642 US9458176, 39

SMILES: C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(CF)c1)-c1ccnc(C)c1

InChI Key: InChIKey=GQYXWCURKTXXOR-CQSZACIVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 252642   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM252642 (US9458176, 39) Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(CF)c1)-c1ccnc(C)c1 |r| Show InChI InChI=1S/C22H21F4N3O2/c1-13-9-15(5-7-27-13)20-18-6-8-30-14(2)12-29(18)21(28-20)16-3-4-19(17(10-16)11-23)31-22(24,25)26/h3-5,7,9-10,14H,6,8,11-12H2,1-2H3/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...				US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D
					More data for this Ligand-Target Pair