BDBM252837 US9458176, 234

SMILES: C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(CF)c1)-c1cc(C)nc(C)c1

InChI Key: InChIKey=WSPJVECWCAXWFX-OAHLLOKOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 252837   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM252837 (US9458176, 234) Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(CF)c1)-c1cc(C)nc(C)c1 |r| Show InChI InChI=1S/C23H24F3N3O2/c1-13-8-17(9-14(2)27-13)21-19-6-7-30-15(3)12-29(19)22(28-21)16-4-5-20(31-23(25)26)18(10-16)11-24/h4-5,8-10,15,23H,6-7,11-12H2,1-3H3/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...				US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D
					More data for this Ligand-Target Pair