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BDBM253034 US9493429, 5

SMILES: CS(=O)(=O)Nc1noc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cc12)C1CC1

InChI Key: InChIKey=KQLTYXFGPMAWBV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 253034   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))		BDBM253034
PNG
(US9493429, 5)
Show SMILES CS(=O)(=O)Nc1noc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cc12)C1CC1 |TLB:16:17:21:15.14.20,20:15:22:19.21.18,20:19:22:15.14.16,THB:16:15:21:22.17.18|
Show InChI InChI=1S/C22H28N2O4S/c1-29(25,26)24-21-18-7-17(16-2-3-16)19(8-20(18)28-23-21)27-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16H,2-6,9-12H2,1H3,(H,23,24)
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.00E+3n/an/an/an/a7.2n/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...

US Patent US9493429 (2016)


BindingDB Entry DOI: 10.7270/Q2X34WDP
More data for this
Ligand-Target Pair