BindingDB PrimarySearch

BDBM253042 US9493447, 1001

SMILES: CCOC(C(=O)c1ccc(o1)-c1cc(OC)c(Cl)c(OC)c1)c1ccc(cc1)-c1nnc(C)s1

InChI Key: InChIKey=QQHJRLKSCSRMEM-UHFFFAOYSA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 253042
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphodiesterase 1A (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
Phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	545	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Isoform 4 (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.74E+3	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.620	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
Phosphodiesterase 7 (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
Phosphodiesterase 8 (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
Phosphodiesterase 9A (PDE9A2) (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.620	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
Phosphodiesterase 11A (PDE11A) (Homo sapiens (Human))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair
Phosphodiesterase 6 (Bos taurus (Bovine))	BDBM253042 (US9493447, 1001) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	7.5	30
Omeros Corporation US Patent					Assay Description The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...				US Patent US9493447 (2016) BindingDB Entry DOI: 10.7270/Q2SB44PB
Omeros Corporation US Patent					More data for this Ligand-Target Pair