BDBM25430 4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitrile::CHEMBL391548::diarylphenol, 5a
SMILES: Oc1ccccc1-c1ccc(C#N)c(c1)C(F)(F)F
InChI Key: InChIKey=CSOANLOTNWGJSK-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Androgen Receptor (Homo sapiens (Human)) | BDBM25430 (4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitril...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 39.9 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Pfizer | Assay Description The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c... | J Med Chem 51: 7010-4 (2008) Article DOI: 10.1021/jm8009316 BindingDB Entry DOI: 10.7270/Q2Z31WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen Receptor (Homo sapiens (Human)) | BDBM25430 (4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitril...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Antagonist activity at human AR in MDA-MB453-MMTV-luci cells by functional assay | Bioorg Med Chem Lett 17: 5529-32 (2007) Article DOI: 10.1016/j.bmcl.2007.08.034 BindingDB Entry DOI: 10.7270/Q2CR5T3S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen Receptor (Homo sapiens (Human)) | BDBM25430 (4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitril...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 39.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]-DHT from human recombinant AR expressed in Sf9 cells | Bioorg Med Chem Lett 17: 5529-32 (2007) Article DOI: 10.1016/j.bmcl.2007.08.034 BindingDB Entry DOI: 10.7270/Q2CR5T3S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM25430 (4-(2-hydroxyphenyl)-2-(trifluoromethyl)benzonitril...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Binding affinity at human PR | Bioorg Med Chem Lett 17: 5529-32 (2007) Article DOI: 10.1016/j.bmcl.2007.08.034 BindingDB Entry DOI: 10.7270/Q2CR5T3S | |||||||||||
More data for this Ligand-Target Pair |