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SMILES: NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccncc12

InChI Key: InChIKey=KOBCARZNSZOJGD-MHWZDGSBSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 254517   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Complement factor D


(Homo sapiens (Human))		BDBM254517
PNG
(US9468661, 95)
Show SMILES NC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC[C@H]2CC2(Cl)Cl)c2ccncc12 |r|
Show InChI InChI=1S/C19H20Cl2N6O3/c20-19(21)5-10(19)6-24-18(30)14-4-9-3-13(9)27(14)15(28)8-26-12-1-2-23-7-11(12)16(25-26)17(22)29/h1-2,7,9-10,13-14H,3-6,8H2,(H2,22,29)(H,24,30)/t9-,10-,13-,14+/m1/s1
PDB

KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 482n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
Method 1: Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compoun...

US Patent US9468661 (2016)


BindingDB Entry DOI: 10.7270/Q23N22B5
More data for this
Ligand-Target Pair