BDBM254785 US9475775, 52::US9597333, 52

SMILES: CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(\C=C/CN)c1

InChI Key: InChIKey=PVSXEDOIPKCQMR-WAYWQWQTSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 254785   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254785 (US9475775, 52 | US9597333, 52) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(\C=C/CN)c1 |t:9,18| Show InChI InChI=1S/C26H32N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h5-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)/b6-5-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254785 (US9475775, 52 | US9597333, 52) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(\C=C/CN)c1 |t:9,18| Show InChI InChI=1S/C26H32N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h5-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)/b6-5-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254785 (US9475775, 52 | US9597333, 52) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(\C=C/CN)c1 |t:9,18| Show InChI InChI=1S/C26H32N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h5-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)/b6-5-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254785 (US9475775, 52 | US9597333, 52) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(\C=C/CN)c1 |t:9,18| Show InChI InChI=1S/C26H32N6O2/c1-3-10-32(11-4-2)26(34)21-13-19-7-8-20(14-23(19)31-24(28)15-21)25(33)30-22-12-18(6-5-9-27)16-29-17-22/h5-8,12-14,16-17H,3-4,9-11,15,27H2,1-2H3,(H2,28,31)(H,30,33)/b6-5-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair