BDBM254922 US9499542, 5::US9675594, 5

SMILES: N#Cc1c[nH]c2nccc(-c3ccc(CN4CCOCC4)cc3)c12

InChI Key: InChIKey=NQDGORODAYJETA-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 254922   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S (Homo sapiens (Human))	BDBM254922 (US9499542, 5 | US9675594, 5) Show SMILES N#Cc1c[nH]c2nccc(-c3ccc(CN4CCOCC4)cc3)c12 Show InChI InChI=1S/C19H18N4O/c20-11-16-12-22-19-18(16)17(5-6-21-19)15-3-1-14(2-4-15)13-23-7-9-24-10-8-23/h1-6,12H,7-10,13H2,(H,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	8.5	30
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent					Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...				US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM254922 (US9499542, 5 | US9675594, 5) Show SMILES N#Cc1c[nH]c2nccc(-c3ccc(CN4CCOCC4)cc3)c12 Show InChI InChI=1S/C19H18N4O/c20-11-16-12-22-19-18(16)17(5-6-21-19)15-3-1-14(2-4-15)13-23-7-9-24-10-8-23/h1-6,12H,7-10,13H2,(H,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.44E+3	n/a	n/a	n/a	n/a
NMMLSC US Patent					Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...				US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S) (Homo sapiens (Human))	BDBM254922 (US9499542, 5 | US9675594, 5) Show SMILES N#Cc1c[nH]c2nccc(-c3ccc(CN4CCOCC4)cc3)c12 Show InChI InChI=1S/C19H18N4O/c20-11-16-12-22-19-18(16)17(5-6-21-19)15-3-1-14(2-4-15)13-23-7-9-24-10-8-23/h1-6,12H,7-10,13H2,(H,21,22)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a
NMMLSC US Patent					Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...				US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM254922 (US9499542, 5 | US9675594, 5) Show SMILES N#Cc1c[nH]c2nccc(-c3ccc(CN4CCOCC4)cc3)c12 Show InChI InChI=1S/C19H18N4O/c20-11-16-12-22-19-18(16)17(5-6-21-19)15-3-1-14(2-4-15)13-23-7-9-24-10-8-23/h1-6,12H,7-10,13H2,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.44E+3	n/a	n/a	n/a	n/a	8.5	30
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent					Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...				US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S
					More data for this Ligand-Target Pair