BDBM254923 US9499542, 6::US9675594, 6

SMILES: N#Cc1c[nH]c2nccc(-c3ccn(CN4CCOCC4)c3)c12

InChI Key: InChIKey=PSCIVEPEARWYTD-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 254923   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S (Homo sapiens (Human))	BDBM254923 (US9499542, 6 | US9675594, 6) Show SMILES N#Cc1c[nH]c2nccc(-c3ccn(CN4CCOCC4)c3)c12 Show InChI InChI=1S/C17H17N5O/c18-9-14-10-20-17-16(14)15(1-3-19-17)13-2-4-22(11-13)12-21-5-7-23-8-6-21/h1-4,10-11H,5-8,12H2,(H,19,20)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	650	n/a	n/a	n/a	n/a	8.5	30
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent					Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...				US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM254923 (US9499542, 6 | US9675594, 6) Show SMILES N#Cc1c[nH]c2nccc(-c3ccn(CN4CCOCC4)c3)c12 Show InChI InChI=1S/C17H17N5O/c18-9-14-10-20-17-16(14)15(1-3-19-17)13-2-4-22(11-13)12-21-5-7-23-8-6-21/h1-4,10-11H,5-8,12H2,(H,19,20)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.87E+3	n/a	n/a	n/a	n/a
NMMLSC US Patent					Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...				US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S) (Homo sapiens (Human))	BDBM254923 (US9499542, 6 | US9675594, 6) Show SMILES N#Cc1c[nH]c2nccc(-c3ccn(CN4CCOCC4)c3)c12 Show InChI InChI=1S/C17H17N5O/c18-9-14-10-20-17-16(14)15(1-3-19-17)13-2-4-22(11-13)12-21-5-7-23-8-6-21/h1-4,10-11H,5-8,12H2,(H,19,20)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	650	n/a	n/a	n/a	n/a
NMMLSC US Patent					Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...				US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM254923 (US9499542, 6 | US9675594, 6) Show SMILES N#Cc1c[nH]c2nccc(-c3ccn(CN4CCOCC4)c3)c12 Show InChI InChI=1S/C17H17N5O/c18-9-14-10-20-17-16(14)15(1-3-19-17)13-2-4-22(11-13)12-21-5-7-23-8-6-21/h1-4,10-11H,5-8,12H2,(H,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.87E+3	n/a	n/a	n/a	n/a	8.5	30
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent					Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...				US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S
					More data for this Ligand-Target Pair