null
SMILES: CN(C)Cc1ccc(cc1C)-c1ccnc2[nH]cc(C#N)c12
InChI Key: InChIKey=MGZVMXARJNUNDE-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human)) | BDBM254925 (US9499542, 8 | US9675594, 8) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 288 | n/a | n/a | n/a | n/a | 8.5 | 30 |
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent | Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ... | US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527] (Homo sapiens (Human)) | BDBM254925 (US9499542, 8 | US9675594, 8) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 549 | n/a | n/a | n/a | n/a |
NMMLSC US Patent | Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th... | US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 [970-2527,G2019S] (Homo sapiens (Human)) | BDBM254925 (US9499542, 8 | US9675594, 8) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 288 | n/a | n/a | n/a | n/a |
NMMLSC US Patent | Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th... | US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM254925 (US9499542, 8 | US9675594, 8) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 549 | n/a | n/a | n/a | n/a | 8.5 | 30 |
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent | Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ... | US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S | |||||||||||
More data for this Ligand-Target Pair |