BDBM254938 US9499542, 21::US9675594, 21

SMILES: Cc1cccc(n1)-c1cc(Nc2nn(C)cc2C(F)(F)F)nc2[nH]cc(C#N)c12

InChI Key: InChIKey=IHVBFXAXYRLAMA-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 254938   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S (Homo sapiens (Human))	BDBM254938 (US9499542, 21 | US9675594, 21) Show SMILES Cc1cccc(n1)-c1cc(Nc2nn(C)cc2C(F)(F)F)nc2[nH]cc(C#N)c12 Show InChI InChI=1S/C19H14F3N7/c1-10-4-3-5-14(25-10)12-6-15(27-18-16(12)11(7-23)8-24-18)26-17-13(19(20,21)22)9-29(2)28-17/h3-6,8-9H,1-2H3,(H2,24,26,27,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	575	n/a	n/a	n/a	n/a	8.5	30
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent					Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...				US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM254938 (US9499542, 21 | US9675594, 21) Show SMILES Cc1cccc(n1)-c1cc(Nc2nn(C)cc2C(F)(F)F)nc2[nH]cc(C#N)c12 Show InChI InChI=1S/C19H14F3N7/c1-10-4-3-5-14(25-10)12-6-15(27-18-16(12)11(7-23)8-24-18)26-17-13(19(20,21)22)9-29(2)28-17/h3-6,8-9H,1-2H3,(H2,24,26,27,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	393	n/a	n/a	n/a	n/a
NMMLSC US Patent					Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...				US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S) (Homo sapiens (Human))	BDBM254938 (US9499542, 21 | US9675594, 21) Show SMILES Cc1cccc(n1)-c1cc(Nc2nn(C)cc2C(F)(F)F)nc2[nH]cc(C#N)c12 Show InChI InChI=1S/C19H14F3N7/c1-10-4-3-5-14(25-10)12-6-15(27-18-16(12)11(7-23)8-24-18)26-17-13(19(20,21)22)9-29(2)28-17/h3-6,8-9H,1-2H3,(H2,24,26,27,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	575	n/a	n/a	n/a	n/a
NMMLSC US Patent					Assay Description In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...				US Patent US9675594 (2017) BindingDB Entry DOI: 10.7270/Q2ZC8110
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM254938 (US9499542, 21 | US9675594, 21) Show SMILES Cc1cccc(n1)-c1cc(Nc2nn(C)cc2C(F)(F)F)nc2[nH]cc(C#N)c12 Show InChI InChI=1S/C19H14F3N7/c1-10-4-3-5-14(25-10)12-6-15(27-18-16(12)11(7-23)8-24-18)26-17-13(19(20,21)22)9-29(2)28-17/h3-6,8-9H,1-2H3,(H2,24,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	393	n/a	n/a	n/a	n/a	8.5	30
H. Lundbeck A/S; Vernalis (R&D) Ltd. US Patent					Assay Description LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...				US Patent US9499542 (2016) BindingDB Entry DOI: 10.7270/Q22N516S
					More data for this Ligand-Target Pair