BDBM25548 4-arylamino-3-pyridinecarbonitrile, 4f::4-{[3-(benzyloxy)phenyl]amino}-5-(3,4-dimethoxyphenyl)pyridine-3-carbonitrile

SMILES: COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cccc(OCc2ccccc2)c1

InChI Key: InChIKey=GYHPISRZZPTKGK-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25548   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C theta type (Homo sapiens (Human))	BDBM25548 (4-arylamino-3-pyridinecarbonitrile, 4f | 4-{[3-(be...) Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3/c1-31-25-12-11-20(13-26(25)32-2)24-17-29-16-21(15-28)27(24)30-22-9-6-10-23(14-22)33-18-19-7-4-3-5-8-19/h3-14,16-17H,18H2,1-2H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	7.2	22
Wyeth Research					Assay Description All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...				J Med Chem 51: 5958-63 (2008) Article DOI: 10.1021/jm800214a BindingDB Entry DOI: 10.7270/Q21V5C8K
					More data for this Ligand-Target Pair