BDBM255510 US10828301, Compound R935307::US9499493, R935307

SMILES: CC(C)Oc1ccc(Nc2nc(Nc3ccc4n(CCCO)ncc4c3)ncc2F)cc1

InChI Key: InChIKey=QVDZEVJCAOLGLZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255510   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255510 (US10828301, Compound R935307 | US9499493, R935307) Show SMILES CC(C)Oc1ccc(Nc2nc(Nc3ccc4n(CCCO)ncc4c3)ncc2F)cc1 Show InChI InChI=1S/C23H25FN6O2/c1-15(2)32-19-7-4-17(5-8-19)27-22-20(24)14-25-23(29-22)28-18-6-9-21-16(12-18)13-26-30(21)10-3-11-31/h4-9,12-15,31H,3,10-11H2,1-2H3,(H2,25,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255510 (US10828301, Compound R935307 | US9499493, R935307) Show SMILES CC(C)Oc1ccc(Nc2nc(Nc3ccc4n(CCCO)ncc4c3)ncc2F)cc1 Show InChI InChI=1S/C23H25FN6O2/c1-15(2)32-19-7-4-17(5-8-19)27-22-20(24)14-25-23(29-22)28-18-6-9-21-16(12-18)13-26-30(21)10-3-11-31/h4-9,12-15,31H,3,10-11H2,1-2H3,(H2,25,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair