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SMILES: CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCC(N)c4c3)n2)c1

InChI Key: InChIKey=BONRMPSOCBJJJO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255515   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255515 (US10828301, Compound R950368 | US9499493, R950368) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCC(N)c4c3)n2)c1 Show InChI InChI=1S/C22H23FN6O3/c1-25-20(30)12-32-15-4-2-3-13(9-15)28-22-26-11-17(23)21(29-22)27-14-5-6-19-16(10-14)18(24)7-8-31-19/h2-6,9-11,18H,7-8,12,24H2,1H3,(H,25,30)(H2,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US10828301 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM255515 (US10828301, Compound R950368 | US9499493, R950368) Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCC(N)c4c3)n2)c1 Show InChI InChI=1S/C22H23FN6O3/c1-25-20(30)12-32-15-4-2-3-13(9-15)28-22-26-11-17(23)21(29-22)27-14-5-6-19-16(10-14)18(24)7-8-31-19/h2-6,9-11,18H,7-8,12,24H2,1H3,(H,25,30)(H2,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...				US Patent US9499493 (2016) BindingDB Entry DOI: 10.7270/Q2WW7GKQ
					More data for this Ligand-Target Pair