BDBM25560 4-(2,3-dihydro-1H-inden-5-ylamino)-5-(3,4-dimethoxyphenyl)pyridine-3-carbonitrile::4-arylamino-3-pyridinecarbonitrile, 4r

SMILES: COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2CCCc2c1

InChI Key: InChIKey=JFJXUGRUMFXVRP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25560   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C theta type (Homo sapiens (Human))	BDBM25560 (4-(2,3-dihydro-1H-inden-5-ylamino)-5-(3,4-dimethox...) Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2CCCc2c1 Show InChI InChI=1S/C23H21N3O2/c1-27-21-9-7-17(11-22(21)28-2)20-14-25-13-18(12-24)23(20)26-19-8-6-15-4-3-5-16(15)10-19/h6-11,13-14H,3-5H2,1-2H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	7.2	22
Wyeth Research					Assay Description All IC50s were measured by using a modified IMAP protocol from Molecular Devices. The kinase reaction was carried out in a Corning Costar 384 well pl...				J Med Chem 51: 5958-63 (2008) Article DOI: 10.1021/jm800214a BindingDB Entry DOI: 10.7270/Q21V5C8K
					More data for this Ligand-Target Pair