BDBM255817 4-Amino-8-(1-{5-chloro-2-methoxy-4-methyl-3-[5-(methylsulfonyl)pyridin-3-yl]phenyl}ethyl)pyrido[2,3-d]pyrimidin-5(8H)-one bis(trifluoroacetate)::US10092570, Example 26::US10376513, Example 26::US10646492, Example 26::US9707233, 26::US9730939, Example 26

SMILES: COc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12

InChI Key: InChIKey=TVKCMRJHVAKGBR-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 255817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110delta/p85alpha (Homo sapiens (Human))	BDBM255817 (4-Amino-8-(1-{5-chloro-2-methoxy-4-methyl-3-[5-(me...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C23H22ClN5O4S/c1-12-17(24)8-16(13(2)29-6-5-18(30)20-22(25)27-11-28-23(20)29)21(33-3)19(12)14-7-15(10-26-9-14)34(4,31)32/h5-11,13H,1-4H3,(H2,25,27,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM255817 (4-Amino-8-(1-{5-chloro-2-methoxy-4-methyl-3-[5-(me...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C23H22ClN5O4S/c1-12-17(24)8-16(13(2)29-6-5-18(30)20-22(25)27-11-28-23(20)29)21(33-3)19(12)14-7-15(10-26-9-14)34(4,31)32/h5-11,13H,1-4H3,(H2,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10092570 (2018) BindingDB Entry DOI: 10.7270/Q2PZ5BW5
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM255817 (4-Amino-8-(1-{5-chloro-2-methoxy-4-methyl-3-[5-(me...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C23H22ClN5O4S/c1-12-17(24)8-16(13(2)29-6-5-18(30)20-22(25)27-11-28-23(20)29)21(33-3)19(12)14-7-15(10-26-9-14)34(4,31)32/h5-11,13H,1-4H3,(H2,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...				US Patent US10646492 (2020)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM255817 (4-Amino-8-(1-{5-chloro-2-methoxy-4-methyl-3-[5-(me...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C23H22ClN5O4S/c1-12-17(24)8-16(13(2)29-6-5-18(30)20-22(25)27-11-28-23(20)29)21(33-3)19(12)14-7-15(10-26-9-14)34(4,31)32/h5-11,13H,1-4H3,(H2,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10376513 (2019) BindingDB Entry DOI: 10.7270/Q2GQ7142
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM255817 (4-Amino-8-(1-{5-chloro-2-methoxy-4-methyl-3-[5-(me...) Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1ccc(=O)c2c(N)ncnc12 Show InChI InChI=1S/C23H22ClN5O4S/c1-12-17(24)8-16(13(2)29-6-5-18(30)20-22(25)27-11-28-23(20)29)21(33-3)19(12)14-7-15(10-26-9-14)34(4,31)32/h5-11,13H,1-4H3,(H2,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...				US Patent US9730939 (2017) BindingDB Entry DOI: 10.7270/Q2GB265W
					More data for this Ligand-Target Pair