null

SMILES: COc1c(cc(Cl)c(C)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key: InChIKey=JVIVLWMFLLLIRQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 255854   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM255854 (1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-oxetan-3-yl...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C22H27ClN6O2/c1-11-17(23)5-16(13(3)29-22-19(12(2)27-29)21(24)25-10-26-22)20(30-4)18(11)14-6-28(7-14)15-8-31-9-15/h5,10,13-15H,6-9H2,1-4H3,(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM255854 (1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-oxetan-3-yl...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C22H27ClN6O2/c1-11-17(23)5-16(13(3)29-22-19(12(2)27-29)21(24)25-10-26-22)20(30-4)18(11)14-6-28(7-14)15-8-31-9-15/h5,10,13-15H,6-9H2,1-4H3,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10092570 (2018) BindingDB Entry DOI: 10.7270/Q2PZ5BW5
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	US11433071, Example 63 (1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-oxetan-3-yl...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C22H27ClN6O2/c1-11-17(23)5-16(13(3)29-22-19(12(2)27-29)21(24)25-10-26-22)20(30-4)18(11)14-6-28(7-14)15-8-31-9-15/h5,10,13-15H,6-9H2,1-4H3,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM255854 (1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-oxetan-3-yl...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C22H27ClN6O2/c1-11-17(23)5-16(13(3)29-22-19(12(2)27-29)21(24)25-10-26-22)20(30-4)18(11)14-6-28(7-14)15-8-31-9-15/h5,10,13-15H,6-9H2,1-4H3,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10376513 (2019) BindingDB Entry DOI: 10.7270/Q2GQ7142
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM255854 (1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-oxetan-3-yl...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C22H27ClN6O2/c1-11-17(23)5-16(13(3)29-22-19(12(2)27-29)21(24)25-10-26-22)20(30-4)18(11)14-6-28(7-14)15-8-31-9-15/h5,10,13-15H,6-9H2,1-4H3,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...				US Patent US10646492 (2020)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM255854 (1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-oxetan-3-yl...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C22H27ClN6O2/c1-11-17(23)5-16(13(3)29-22-19(12(2)27-29)21(24)25-10-26-22)20(30-4)18(11)14-6-28(7-14)15-8-31-9-15/h5,10,13-15H,6-9H2,1-4H3,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...				US Patent US9730939 (2017) BindingDB Entry DOI: 10.7270/Q2GB265W
					More data for this Ligand-Target Pair