BDBM25668 4-[(5-bromo-1,3-thiazol-2-yl)amino]benzonitrile::aminothiazole analogue, 12

SMILES: Brc1cnc(Nc2ccc(cc2)C#N)s1

InChI Key: InChIKey=LGRGXAHTQGDCSK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25668   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM25668 (4-[(5-bromo-1,3-thiazol-2-yl)amino]benzonitrile | ...) Show SMILES Brc1cnc(Nc2ccc(cc2)C#N)s1 Show InChI InChI=1S/C10H6BrN3S/c11-9-6-13-10(15-9)14-8-3-1-7(5-12)2-4-8/h1-4,6H,(H,13,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	7.0	22
Novartis					Assay Description The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...				ACS Chem Biol 3: 180-92 (2008) Article DOI: 10.1021/cb700200w BindingDB Entry DOI: 10.7270/Q2HX1B03
					More data for this Ligand-Target Pair