BDBM25679 aminothiazole analogue, 23::ethyl 4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoate

SMILES: CCOC(=O)c1ccc(Nc2ncc(Br)s2)cc1

InChI Key: InChIKey=UCNQZHJDGNKKCF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25679   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM25679 (aminothiazole analogue, 23 | ethyl 4-[(5-bromo-1,3...) Show SMILES CCOC(=O)c1ccc(Nc2ncc(Br)s2)cc1 Show InChI InChI=1S/C12H11BrN2O2S/c1-2-17-11(16)8-3-5-9(6-4-8)15-12-14-7-10(13)18-12/h3-7H,2H2,1H3,(H,14,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	7.0	22
Novartis					Assay Description The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...				ACS Chem Biol 3: 180-92 (2008) Article DOI: 10.1021/cb700200w BindingDB Entry DOI: 10.7270/Q2HX1B03
					More data for this Ligand-Target Pair