BDBM256955 US9493432, 81
SMILES: CN([C@H]1CCC[C@@H]1Nc1nc2ccc(F)cc2s1)C(=O)c1cc(F)ccc1-n1nccn1
InChI Key: InChIKey=AWDZNHIULYTTNC-LPHOPBHVSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Orexin receptor type 2 (Homo sapiens (Human)) | BDBM256955 (US9493432, 81) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | 37 |
Takeda Pharmaceuticals Company Limited US Patent | Assay Description Orexin antagonist activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in... | US Patent US9493432 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VJT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Orexin receptor type 1 (Homo sapiens (Human)) | BDBM256955 (US9493432, 81) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 37 |
Takeda Pharmaceuticals Company Limited US Patent | Assay Description Orexin antagonist activity was determined by measuring changes in intracellular calcium levels using a Ca2+ sensitive fluorescent dye. The changes in... | US Patent US9493432 (2016) BindingDB Entry DOI: 10.7270/Q2FQ9VJT | |||||||||||
More data for this Ligand-Target Pair |