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SMILES: CC1(C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2nc(ccc12)C(F)(F)F

InChI Key: InChIKey=ZCJFNPXWYHVQBH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 258381   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM258381
PNG
(US9505786, 19)
Show SMILES CC1(C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C21H15F4N7O/c1-20(2)15-17(28-19(20)33)27-16(30-29-15)14-11-7-8-13(21(23,24)25)26-18(11)32(31-14)9-10-5-3-4-6-12(10)22/h3-8H,9H2,1-2H3,(H,27,28,30,33)
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US Patent
n/an/a 38n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...

US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair