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SMILES: CCOC(=O)\C=C\c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12

InChI Key: InChIKey=XIQIZZMMICDQMS-VAWYXSNFSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 258389   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM258389
PNG
(US9505786, 27)
Show SMILES CCOC(=O)\C=C\c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C26H23FN6O3/c1-4-36-19(34)12-11-18-20-22(31-25(35)26(20,2)3)30-23(29-18)21-16-9-7-13-28-24(16)33(32-21)14-15-8-5-6-10-17(15)27/h5-13H,4,14H2,1-3H3,(H,29,30,31,35)/b12-11+
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US Patent
n/an/a 215n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...

US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair